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Moreover, the percentage of these lipids in thylakoid membranes and isolated PSIIRC is practically the same. Hence, the MGDG and DGDG, which interact with PSIIRC,Dasatinib Src-bcr-Abl inhibitor may experience the aforementioned 18:3R18:1 and 16:1R16:0 transition under prolonged temperature elevation. The resulting rigidification of the lipids interacting with D1/D2 proteins should modify any process involving a protein conformational change that requires displacement of these lipids. The experimental values of the thermodynamic parameters fit the putative conformational changes and the involved energies that are presented in Figure 6, following the DFT computations. Thus the thermodynamic parameters show both stabilization of the ground state and enhanced EX 527 HDAC inhibitor conformational rigidity of the AC after acclimation at the elevated temperature. Such enhancement is often proposed to account for the increased thermal stability of thermophilic enzymes compared with mesophiles. The significance of fatty acid saturation in regulating enzymatic reactions that depend on protein conformational changes, was explored using lipid specificity for the reconstitution of wellcoupled ATPase proteoliposomes.