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 Post subject: Additionally the maintenance of red bone marrow means the bo
PostPosted: Wed Jan 24, 2018 5:24 am 
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Joined: Wed Jul 31, 2013 1:53 am
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Additionally the maintenance of red bone marrow means the bone marrow will retain
More microvessels, unlike BAY-60-7550 PDE inhibitor fatty bone marrow, which is not as well vascularized. The Sal B treatment further increased marrow angiogenesis that increases blood flow to improve nutrition and source of circulating progenitors. In support of osteogenesis, stimulated angiogenesis reduced intraosseous pressure that increases blood flow and in turn stimulates osteoblastic activity. Further red bone marrow sites with better vasculature exhibit a factor of 10 higher bone remodeling and formation rates than fatty marrow bone sites. Also the improved blood flow increases osteocyte lacunarcanaliculi and blood vessel fluid volume that increase bone strength and reduce the risk of fracture. To clarify the mechanism by which Sal B promotes osteoblast differentiation and alleviates GC-induced impairment of bone formation, we examined the effects of Sal B on primary rat calvarial osteoblasts BEZ235|NVP-BEZ235 PI3K inhibitor and rat bone marrow stromal cell by upregulating Wnt/b-catenin signaling. Our data showed that Sal B stimulates osteoblast cell growth and MSC differentiation into osteoblast maturation with a dose and time dependent manner that mimicks the action of osteoblast inducer. This study further demonstrated that Sal B activated Runx2 and b-catenin mRNA expression and declined DKK-1 and PPARc mRNA expression which had been induced by GC.


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